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Enhancing memory

Do you want to be a person who has a good memory? People who enjoy their wonderful memory often do well in their studies and work. It’s been predicted that by 2050, more than 80-90 million people, age 65 and over, will be affected by age-related neurodegenerative disorders. More people are turning to alternative measures to help prevent that. Current studies found some mushroom do have the function to improve people’s memory.

A nootropic mushroom called Hericium erinaceus (Lion’s Mane) is drawing lots of attention for its notable nerve-regenerative properties, which is very important to improve memory. Federico Brandalisestudied the dietary supplementation with H. erinaceus prevents the impairment of spatial short-term and visual recognition memory in an Alzheimer model. In wild-type mice, they found the oral supplementation with H. erinaceus induces, in behaviour test, a significant improvement in the recognition memory and, in hippocampal slices, an increase in spontaneous and evoked excitatory synaptic current in mossy fiber-CA3 synapse. The study got the conclusion that H. erinaceus induces a boost effect onto neuronal functions also in nonpathological conditions.

Koichiro Moriand other authors examined the effects of H. erinaceus on amyloid β (25-35) peptide-induced learning and memory deficits in mice. Mice were administered 10 μg of amyloid β (25-35) peptide intracerebroventricularly on days 7 and 14, and fed a diet containing H. erinaceus over a 23-d experimental period. Memory and learning function were examined using behavioral pharmacological methods including the Y-maze test and the novelobject recognition test. The results revealed that H. erinaceus prevented impairments of spatial short-term and visual recognition memory induced by amyloid β (25-35) peptide. This finding indicates that H. erinaceus may be useful in the prevention of cognitive dysfunction.

A systematic review was undertaken of the evidence by Amelie Nkodo3on the use of Hericium erinaceus (Lion's mane ), Ganoderma lucidum (Reishi), Ophiocordyceps sinensis (Cordyceps) and Cordyceps militaris (Cordyceps), dietary supplementation on cognitive impairment outcomes. The results of this review suggest that dietary supplementation with lion’s mane, reishi and cordyceps mushrooms may have a beneficial effect on cognitive impairment.3

Koichiro Moridid a clinic trial about the effect of lion’s mane on old people’s memory. The study was performed on 50-to 80-year-old Japanese men and women diagnosed with mild cognitive impairment in order to examine the efficacy of oral administration of Yamabushitake (Lion’s mane), for improving cognitive impairment, using a cognitive function scale based on the Revised Hasegawa Dementia Scale (HDS-R).The results obtained in this study suggest that Yamabushitake is effective in improving mild cognitive impairment.

The neuroprotective effects of G.lucidum and its extracts on brain injury diseases, including Alzheimer’s disease, Parkinson’s disease, stroke, epilepsy, and other neurodegenerative diseases, and the potential clinical applications was researched in the book Ganoderma and Health. It showed reishi has good clinical application prospects for cerebrovascular disease, Alzheimer’s disease, Parkinson’s disease, and epilepsy. In the future, G. lucidum can be further studied for other diseases of the nervous system such as myasthenia gravis and peripheral neuropathy.5

1Federico Brandalise et al, Dietary Supplementation of Hericium erinaceus Increases Mossy Fiber-CA3 Hippocampal Neurotransmission and Recognition Memory in Wild-Type Mice, Evidence-Based Complementary and Alternative Medicine,Volume 2017, Article ID 3864340, 13 pages,

2Koichiro Mori, Yutaro Obara, Takahiro Moriya, Satoshi Inatomi, Norimichi Nakahata, Effects of Hericium erinaceus on amyloid β(25-35) peptide-induced learning and memory deficits in mice, Biomedical Research,2011 Volume 32 Issue 1 Pages 67-72


3Amelie Nkodo, A Systematic Review of in-vivo Studies on Dietary Mushroom Supplementation for Cognitive Impairment (P14-021-19), 1302 Neuroscience, Cognitive Function and Chronobiology


4Koichiro Mori, Satoshi Inatomi, Kenzi Ouchi,Yoshihito Azumi, and Takashi Tuchida, Improving Effects of the Mushroom Yamabushitake (Hericium erinaceus) on Mild Cognitive Impairment: A Double-blind Placebo-controlled Clinical Trial, Phytother. Res.23,367-372(2009)


5Yazhu Quan, Ang Ma, and Baoxue Yang, Preventive and Therapeutic Effect of Ganoderma (Lingzhi) on Brain Injury, Ganoderma and Health, Advances in Experimental Medicine and Biology 1182,



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